Tag: M.W:200-300

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole, molecular formula is C14H11NS. In a Article，once mentioned of 16112-21-3, Safety of 2-(4-Methylphenyl)benzothiazole

2-Aminobenzenethiol and an aryl aldehyde were allowed to react to give a 2-arylbenzothiazole in good yield in the presence of a catalytic amount of scandium triflate Sc(OTf)3. The detailed study showed that Sc(OTf)3 catalyzed two steps, that is, the formation of a thiazoline ring and the oxidation of the thiazoline to a thiazole ring. This is the first example that scandium(III) ion catalyzed oxidation of an organic compound using molecular oxygen as an oxidant. The reaction was applied to o-phenylenediamine and an aryl aldehyde to give corresponding 2-arylbenzimidazole in moderate to good yields depending upon the structure of aldehyde.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 16112-21-3 is helpful to your research., Safety of 2-(4-Methylphenyl)benzothiazole

Reference：
Thiazole | C3H909NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.61296-22-8, Name is 2-Amino-5-bromothiazole monohydrobromide, molecular formula is C3H4Br2N2S. In a Patent，once mentioned of 61296-22-8, Formula: C3H4Br2N2S

Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives.The disclosure also provides use of a compound of formula (I) its polymorphs, stereoisomers, pharmaceutically acceptable salt, solvate or pro-drug thereof, for the manufacture of a medicament for the activation of Glucokinase.Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment, control of progression, or adjunct treatment of diseases and/or medical conditions where the activation of glucokinase would be beneficial, are disclosed. The disclosure also provides process of preparation of these acetamide derivatives. The disclosure also provides use of a compound of formula (I) its polymorphs, stereoisomers, pharmaceutically acceptable salt, solvate or pro-drug thereof, for the manufacture of a medicament for the activation of Glucokinase.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C3H4Br2N2S, you can also check out more blogs about61296-22-8

Reference：
Thiazole | C3H2119NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 2942-23-6. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 2942-23-6, Name is 2,7-Dichlorobenzo[d]thiazole. In a document type is Patent, introducing its new discovery.

Compositions including derivatives of spinosyns of the following formulae and methods for the production of derivatives of spinosyns are provided. The spinosyn derivatives described herein include those functionalized on the C-5,6 double bond to provide an aziridine ring system. The method produces spinosyn derivatives that exhibit activity towards insects, arachnids, and nematodes and are useful in the agricultural and animal health markets.

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Reference：
Thiazole | C3H1758NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 344-72-9. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 344-72-9, Name is Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate. In a document type is Article, introducing its new discovery.

A series of thiazolidenebenzenesulfonamides have been discovered as nonnucleoside reverse transcriptase inhibitors. Compound 17a exhibited the most potent inhibitory activity against the Y181C mutant reverse transcriptase (RT). The introduction of the 4-chloro-5-isopropyl moiety (17k) markedly increased the activity against the wild type RT. Both 17a and 17k strongly inhibited HIV-1 replication. A random high-throughput screening (HTS) program to discover novel nonnucleoside reverse transcriptase inhibitors (NNRTIs) has been carried out with MT-4 cells against a nevirapine-resistant virus, HIV-1IIIB-R. The primary hit, a thiazolidenebenzenesulfonamide derivative, possessed good activity. A systematic modification program examining various substituents at the 3-, 4-, and 5-positions on the thiazole ring afforded compounds with enhanced anti-HIV-1 and reverse transcriptase (RT) inhibitory activities. These results confirm the important role of the substituents at these positions and the thiazolidenebenzenesulfonamide motif as a valuable lead series for the next generation NNRTIs.

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Reference：
Thiazole | C3H7934NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.16311-69-6, Name is 5-(2-Hydroxyethyl)-3,4-dimethylthiazol-3-ium iodide, molecular formula is C7H12INOS. In a Article，once mentioned of 16311-69-6, Product Details of 16311-69-6

A detailed study of the fluorescence and phosphorescence characteristics of thiamine (Vitamin B1), thiamine pyrophosphate (cocarboxylase), and a number of related compounds has been undertaken.The attempt to enhance the phosphorescence of thiamine by several external heavy-atom species resulted in a new emission band, which has been assigned to a charge-transfer state.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 16311-69-6, you can also check out more blogs about16311-69-6

Reference：
Thiazole | C3H5958NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine,molecular formula is C8H5F3N2S, is a conventional compound. this article was the specific content is as follows.Computed Properties of C8H5F3N2S

The present invention provides a compound of general formulae A useful as potential anti-cancer agents against human cancer cell lines and a process for the preparation thereof. Where in R, R1, R2?H, alkyl, alkoxy, halo, haloalkyl, halomethoxy, nitro and G= Where in R, R1, R2?H, alkyl, alkoxy, halo, haloalkyl, halomethoxy, nitro and G=

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Reference：
Thiazole | C3H6688NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 16582-58-4, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.16582-58-4, Name is 6-Iodobenzo[d]thiazol-2-amine, molecular formula is C7H5IN2S. In a patent, introducing its new discovery.

7-(4-Bromobutoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one, obtained from chrysin with 1,4-dibromobutane, was combined with a wide range of 6-substituted 2-aminobenzthiazoles, which had been prepared from the corresponding anilines with potassium thiocyanate. Free radical scavenging efficacies of newer analogues were measured using DPPH and ABTS assays, in addition to the assessment of their anticancer activity against cervical cancer cell lines (HeLa and CaSki) and ovarian cancer cell line (SK-OV-3) implementing the SRB assay. Cytotoxicity of titled compounds was checked using Madin-Darby canine kidney (MDCK) non-cancer cell line. Overall, 6a-r indicated remarkable antioxidant power as DPPH and ABTS+ scavengers; particularly the presence of halogen(s) (6g, 6h, 6j-6l) was favourable with IC50 values comparable to the control ascorbic acid. Unsubstituted benzothiazole ring favored the activity of resultant compounds (6a and 6r) against HeLa cell line, whereas presence of chlorine (6g) or a di-fluoro group (6k) was a key to exert strong action against CaSki. Moreover, a mono-fluoro (6j) and a ketonic functionality (6o) were beneficial to display anticipated anticancer effects against ovarian cancer cell line SK-OV-3. The structural assignments of the new products were done on the basis of IR, 1H NMR, 13C NMR spectroscopy and elemental analysis.

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Reference：
Thiazole | C3H7104NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 80945-86-4, An article , which mentions 80945-86-4, molecular formula is C7H3BrClNS. The compound – 6-Bromo-2-chlorobenzothiazole played an important role in people’s production and life.

This work reports a simple, efficient and alternative synthetic route for the preparation of benzoxazoles via tandem cyclization of 2-halophenols with amidines. The developed methodology is free from ligands and uses inexpensive and easily available CuCl as a catalyst. This protocol avoids the use of any oxidant or inorganic acids. Various benzoxazole derivatives were synthesized in good to excellent yields. To the best of our knowledge, this is the first time that the synthesis of benzoxazoles from 2-halophenols with both aromatic and aliphatic amidines is reported. Owing to the simplicity of this protocol, the preparation of benzoxazoles could be achieved at a gram scale level.

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Reference：
Thiazole | C3H10857NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 51618-29-2. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 51618-29-2, Name is 6-Chlorobenzo[d]thiazole-2-thiol. In a document type is Article, introducing its new discovery.

Ten new organometallic half-sandwich ruthenium complexes with heterocyclic ligands have been synthesized (H1-H10). The substituents on the ancillary heterocyclic ligands were varied to understand the effect of substitution on anticancer activity. The crystallographic characterization of five complexes confirms that they adopt “three-legged piano-stool” structures and are stabilized by intramolecular hydrogen bonding. Complexes H2 and H3 also exhibit halogen bonding in the solid state. In aqueous media, the complexes form dinuclear ruthenium species. Complex H1 with a noncytotoxic heterocycle, 6-fluoro-2-mercaptobenzothiazole, and complex H11 with the unsubstituted 2-mercaptobenzothiazole are the most active against A2780 and KB cell lines. The substitution of the H atoms on the ancillary ligand with Cl or Br atoms leads to a decrease in the anticancer activity. With the exception of fluorine-substituted H5, the complexes with mercaptobenzoxazole (H6-H9) are inactive against all of the tested cell lines. Ruthenium complexes with mercaptonaphthimidazole (H10) and mercaptobenzimidazole (H13) do not show any anticancer activity. The active complexes show a biphasic melting curve when incubated with calf thymus (CT) DNA. These complexes only inhibit thioredoxin reductase (TrxR) enzyme activity to a small extent. The substitution of hydrogen atoms with fluorine atoms in the aromatic heterocyclic ligands on organometallic half-sandwich ruthenium complexes has the most beneficial effect on their anticancer activity.

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Reference：
Thiazole | C3H6994NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 78485-37-7, An article , which mentions 78485-37-7, molecular formula is C10H8ClNO2S. The compound – Ethyl 2-chloro-6-benzothiazolecarboxylate played an important role in people’s production and life.

Starting from the structure of thioperamide, a known H3-antagonist, a new series of compounds with a benzothiazole nucleus instead of the cyclohexylcarbothioamide moiety was synthesized. Various substituents, selected by experimental design, were introduced in position 6 of the benzothiazole nucleus, in order to change its physico-chemical characteristics. The lipophilicity of the synthesized compounds was measured by means of RP-HPLC, and their H3-receptor affinity was evaluated by competitive binding assays on rat cortex synaptosomes, with the labelled ligand N(alpha)-[3H]methylhistamine. A QSAR analysis was performed on the experimental data, using also substituent constants taken from the literature. The newly synthesized compounds showed lower H3-affinities than thioperamide; quantitative structure-activity relationships, described by models obtained with PLS and MRA techniques, were observed among benzothiazole derivatives. According to these relationships, any attempt to improve the potency of these compounds should involve the substitution of the benzothiazole moiety with less bulky and/or more flexible structures, which should also be less lipophilic and allow better electronic interactions with the binding site. 1-(Benzothiazol-2-yl)-4-[(1H)-imidazol-4-yl]piperidine represents a limit structure for H3-activity, since it seems impossible to improve its affinity by means of substitution in the studied position of the benzothiazole nucleus, as shown by predictions performed by a PLS model.

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Reference：
Thiazole | C3H8083NS – PubChem,
Thiazole | chemical compound | Britannica