Tag: M.W:300-400

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 161798-03-4, Name is Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate, molecular formula is C18H21NO4S. In a Patent, authors is KOFTIS, Theocharis, V.£¬once mentioned of 161798-03-4, 161798-03-4

The present invention relates to a novel preparation method for 2-(3-cyano-4-isobutoxyphenyl)- 4-methyl-1,3-thiazole-5-carboxylic acid (Febuxostat) via novel and high yielded conversion of a formyl group in to a cyano group.

The present invention relates to a novel preparation method for 2-(3-cyano-4-isobutoxyphenyl)- 4-methyl-1,3-thiazole-5-carboxylic acid (Febuxostat) via novel and high yielded conversion of a formyl group in to a cyano group.

161798-03-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 161798-03-4

Reference£º
Thiazole | C3H7758NS – PubChem,
Thiazole | chemical compound | Britannica

72850-79-4, Ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,72850-79-4

A mixture of 2-bromothiazole 8 (152 mg, 0.50 mmol), Et3N (0.28 mL, 2.0 mmol, 4.0 equiv) and the appropriate isothiouronium salt (233 mg, 1.0 mmol, 2.0 equiv) were heated using MW irradiation at 130 C for 30 mins. The solvent was removed under reduced pressure and the orange residue was reconstituted in EtOH (5 mL) and treated with LiOH¡¤H2O (107 mg, 2.55 mmol, 5.1 equiv) for 5 h. The reaction mixture was concentrated under reduced pressure and partitioned between CH2Cl2 (10 mL) and H2O (10 mL). The isolated aqueous phase was made acidic (pH = 1) using 2 M HCl (ca. 3 mL) and extracted using CH2Cl2/EtOH (9:1, 4 ¡Á 10 mL). The combined organic extract was dried (MgSO4), filtered and concentrated to give the title compound (75 mg, 43%) as a white powder;

72850-79-4 Ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate 13282759, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Hickey, Shane M.; White, Jonathan M.; Pfeffer, Frederick M.; Ashton, Trent D.; Synlett; vol. 26; 12; (2015); p. 1759 – 1763;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

172.8 g of formic acid and16.0 g of ethyl 2-(3-formyl-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylate (FBT-1) prepared in Example 1 were added to a 500 ml round bottom flask, 4.2g hydroxylamine hydrochloride and 4.1g sodium formate were added, and stirred at 105 ~ 110 C for 2h. After completion of the reaction, cooled to 20 ~ 30 C, heat crystallization was carried out for 1h, filtered, filter cake was washed with 25.3g ethanol, filtered, dried and 14.2 g of ethyl 2-(3-cyano-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylate (FBT-2) was obtained in a yield of 89.5%., 161798-03-4

The synthetic route of 161798-03-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hunan Fangsheng Pharmaceutical Co., Ltd.; Zhang Qinghua; Chen Bo; Yan Zhiyong; (6 pag.)CN109912531; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

173979-01-6, 4-(Tributylstannyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of ethyl 3-(2-(6-chioro-3-cvano- 4-methyipyridin-2-yi)-5-fluoro- I ,2,3,4-tetrahydroisoquinolin-6-yI)propanoate (50 mg, 0.124 mrnol) and 4-(tributylstannyi)thiazoie (51.2 mg, 0.137 mrnol) in dioxane (3 ml) was added (i2 XPhos (979mg. 0.012 mmol). The mixture was stirred at 110 c for 12 h, then quenched with 10% aqueous KF (10 ml), filtered and extracted with ethyl acetate (8 niL x 3). The organic layers were combined and washed with water (15 mL), brine (10 mL), dried over Na2SO4,filtered and concentrated under reduced pressure to afford the title compound, which was used directly without further purification., 173979-01-6

173979-01-6 4-(Tributylstannyl)thiazole 2763258, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ADAMS, Gregory, L.; COX, Jason, M.; DEBENHAM, John, S.; EDMONDSON, Scott; GILBERT, Eric, J.; GUO, Yan; JIANG, Yu; JOSIEN, Hubert; KIM, Hyunjin, M.; LAN, Ping; MIAO, Shouwu; PLUMMER, Christopher, W.; RAJAGOPALAN, Murali; SHAH, Unmesh; SUN, Zhongxiang; TRUONG, Quang, T.; UJJAINWALLA, Feroze; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; SUZUKI, Takao; WANG, Nengxue; (182 pag.)WO2017/205193; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

668484-45-5, 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

668484-45-5, 2-(4-(tert-butoxycarbonyl)piperazin- 1 -yl)thiazole4-carboxylic acid (156 mg, 0.5 mmol), tert-butyl 2-amino-4-(thiophen-2-yl) phenylcarbamate (130 mg, 0.45 mmol) and EDCI (191 mg, 1 mmol) were added into Py (5 ml). The mixture was stirred at room temperature for overnight. When the reaction finished, it was concentrated and water was added. The yellow solid was collected as product (210 mg, 80% yield).

As the paragraph descriping shows that 668484-45-5 is playing an increasingly important role.

Reference£º
Patent; Regenacy Pharmaceuticals, LLC; van Duzer, John H.; Mazitschek, Ralph; (123 pag.)US2018/141923; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

161798-03-4, Example 3Preparation of 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (FBZC)To a 500 ml three-necked bottle was added 28.0 g of ethyl 2-[3-formyl-4-(2-methyl propoxy)phenyl]-4-methyl-5-thiazolcarboxylate, 280 ml of 10% sodium hydroxide solution and 90 ml of ethanol, the reaction was performed under stirring at about 80 C. for about 4 h, then the reaction stopped, cooled, adjusted by adding dropwise slowly a concentrated hydrochloride to about pH 3. A white solid was precipitated and filtered. The filter cake was washed with water, and dried by vacuum sucking. The filter cake was recrystallized with ethyl acetate, filtered, then dried at 70-75 C. in a reduced pressure (-0.080 to -0.085 MPa) to obtain 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (FBZC) (11.2 g) as a white crystalline. Purity (by HPLC): 99%. IR (KBr): 3432, 2966, 2871, 1679, 1652, 1605, 1513, 1447, 1427, 1371, 1179, 1111, 1014 cm-1. 1H-NMR (500 MHz, DMSO-d6) delta (ppm): 13.360 (1H, s), 10.397 (1H, s), 8.191-8.153 (2H, m), 7.337-7.319 (1H, d), 3.990-3.977 (2H, d), 2.659 (3H, s), 2.163-2.084 (1H, s), 1.045-1.031 (6H, d).

161798-03-4 Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 10904158, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO/. LTD.; US2011/282069; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

To the solution of ethyl 2-[3-formyl-4-(2-methylpropoxy) phenyl]-4- methylthiazole-5-carboxylate compound of formula-12 (10 gms) in formic acid (40 ml) was added hydroxylamine hydrochloride (2.38 gms) and sodium formate (2.35 gms).Stirred the reaction mixture for 10 minutes. Heated the reaction mixture to 100C and stirred for four hours at same temperature. Cooled the reaction mixture to 25 C and quenched with water. Stirred the reaction mixture for 10 hours, filtered the precipitated solid and washed with water. Dried the material to get the title compound. Yield: 10 gms. Take the dry material, added 30 ml of ethyl acetate and heated to reflux temperature. Stirred the reaction mixture for 30 minutes at reflux temperature. Cooled the reaction mixture to 25C and filtered the precipitated solid. Dry the material to get the title compound as a pure material. Yield: 8.5 gms.

161798-03-4, As the paragraph descriping shows that 161798-03-4 is playing an increasingly important role.

Reference£º
Patent; MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; VENKATA PANAKALA RAO, Gogulapati; PRASAD, Gadamsetty; WO2011/141933; (2011); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

173979-01-6, 4-(Tributylstannyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 63 (3-Chloro-5-thiazol-4-yl-phenyl)-(1 H-imidazol-2-yl)-methanoneA solution of Example 53 (50 mg, 0.15 mmol) in 1 ,4-dioxane (3 ml_) was stirred in a microwave reaction tube. 4-Tributylstannanyl-thiazole (62 mg, 0.165 mmol) followed by Pd(PPh3)4 (10 mg, 8.6 mumol) was added to the stirred mixture. The tube was sealed and the reaction was heated at 1200C for 30 mins. The mixture was then diluted with EtOAc (20 ml.) and washed with brine. The organic phase was then dried over Na2SO4, filtered and the solvent evaporated. The crude was triturated in dichloromethane and the collected precipitate was purified further by SiO2 chromatography (Hexanes/ EtOAc; 9:1 to 2:1 ) to give the title compound as a beige solid (10 mg, 23%). MS(ESI) m/z 289.9 (M+H)+. 1H NMR (400 MHz, DMSO-d6): 13.62 (1 H, s), 9.28 (1 H, d), 8.97 (1 H, t), 8.58 (1 H, t), 8.46 (1 H, d), 8.34 (1 H, t), 7.58 (1 H, s), 7.39 (1 H, s).

173979-01-6, The synthetic route of 173979-01-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; ASTEX THERAPEUTICS LIMITED; HOWARD, Steven; MORTENSON, Paul Neil; HISCOCK, Steven Douglas; WOOLFORD, Alison Jo-Anne; WOODHEAD, Andrew James; CHESSARI, Gianni; O’REILLY, Marc; CONGREVE, Miles Stuart; DAGOSTIN, Claudio; CHO, Young Shin; YANG, Fan; CHEN, Christine Hiu-Tung; BRAIN, Christopher Thomas; LAGU, Bharat; WANG, Yaping; KIM, Sunkyu; GRIALDES, John; LUZZIO, Michael Joseph; PEREZ, Lawrence Blas; WO2010/125402; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

c) Preparation of Ethyl 2-(3-cvano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate [Compound of formula V]. 350.0gm of Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate, [Compound of formula IV] 123.0gm of sodium formate followed by 84.0gm of hydroxylamine hydrochloride were added to 1.4 ltr of formic acid. Reaction mixture was heated to reflux and stirred for 5hr to complete the reaction. Reaction solution was cooled to 25C. Slowly added 2.8 ltr of water at 25C. Slurry formed was stirred for about l.Ohr, filtered, washed with water and dried under vacuum to give 321.0gm of titled compound.Analytical Data- ¡¤ ^NMR (CDC13, 400 MHz) : delta 1.053-1.104 (doublet, 6H); delta 1.368-1.416 (triplet,3H); delta 2.164-2.253 (multiplet, 1H); delta 2.768 (singlet, 3H); delta 3.890-3.911 (doublet, 2H); delta 4.324-4.395 (quartet, 2H); delta 6.998-7.027 (doublet, 1H); delta 8.075-8.112 (doublet of doublet, 1H); delta 8.175-8.182 (doublet, 1H).? Mass (m/e) : 345.2, 161798-03-4

The synthetic route of 161798-03-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANDOZ AG; LUTHRA, Parven, Kumar; KHAN, Rashid; SALUNKHE, Dadasaheb; NASIR ALI, Shafakat, Ali; WO2012/131590; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160844-75-7,Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate,as a common compound, the synthetic route is as follows.

Preparation of febuxostat without isolation of intermediate ethyl-2-(3-cyano-4- isobutoxyphenyl)-4-methyl thiazole-5-carboxylate 3-cyano-4-isobutoxyphenyl boronic acid (5.0 gms/0.02283 moles), ethyl-2-bromo-4-methylthiazole-5-carboxylate (5.70 gms/0.02289 moles) and 50 ml of 2M aqueous sodium carbonate solution were charged in 75 ml toluene, followed by tetrakis (triphenyl phosphine) palladium (1.5 gms). The resultant mixture was stirred at 70- 75¡ãC for 1 hour. The reaction mass was cooled to 25¡ãC and extracted in ethyl acetate (30ml). The organic layer was washed with brine, dried over anhydrous sodium sulphate and the clear filtrate was distilled off completely.The residue was stirred in 40 ml THF under inert atmosphere. To the reaction mass, 2N NaOH (11 ml) was slowly added at 25-30¡ãC and stirred further at reflux for 5 hours. The reaction mass was cooled to 25¡ãC and filtered through celite. The reaction mass was acidified with diluted concentrated HCI. The reaction mass was further stirred for 30 minutes. The resulting solid was isolated by filtration, washed with water until a neutral pH and dried under vacuum to yield 3.3 gms of the titled compound. Efficiency: 72percent, 160844-75-7

The synthetic route of 160844-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CIPLA LIMITED; BIRARI, Dilip, Ramdas; RAO, Dharmaraj, Ramachandra; KANKAN, Rajendra, Narayanrao; CURTIS, Philip, Anthony; WO2011/73617; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica