Tag: M.W=500-550

Lupina, Katarzyna published the artcileControlled release of water-soluble astaxanthin from carboxymethyl cellulose/gelatin and octenyl succinic anhydride starch/gelatin blend films, HPLC of Formula: 30931-67-0, the publication is Food Hydrocolloids (2022), 107179, database is CAplus.

The effect of increasing concentrations (0, 0.25, 0.5, 1%) of com. water-soluble AstaSana astaxanthin (AST) on the physicochem. properties, release kinetics and antioxidant activity of binary 75/25 CM-cellulose/gelatin (CMC75/GEL25) and octenyl succinic anhydride starch/gelatin (OSA75/GEL25) blend films was investigated. The microscopic observations showed that the obtained blends were phase-separated systems. Regardless of the AST concentration, the CMC-based films were more opaque, stronger, and less stretchable than the OSA-based films. The AST-supplemented films exhibited an intensive red color. The starch granules (from the AST formulation) contributed to high roughness and opacity of the films. The presence of AST contributed to a significant decrease of the puncture strength and oxygen permeability of the CMC-based film. The AST-supplemented films did not differ in terms of the water vapor barrier properties. Due to the low quantity of astaxanthin in the systems, the Fourier-transform IR spectra of the control and AST-supplemented films were similar. The increase in the AST concentration was accompanied by reduced solubility and increased swelling of the OSA-based films, while an opposite result was observed for the CMC-based films. According to the Korsmeyer-Peppas with time lag model, the AST release kinetics exhibited quasi-Fickian behavior. Due to their weaker solubility, the OSA75/GEL25 films offered at least 7 times slower release of AST than the CMC-based carrier. The times required for 25% AST release from the CMC75/GEL25 and OSA75/GEL25 films were 1.20-1.74 and 12.60-20.04 min, resp. A high pos. correlation (R² = 0.78-0.91) was found between the AST release and antiradical activity of the films.

Food Hydrocolloids published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, HPLC of Formula: 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Seczyk, Lukasz published the artcileIn vitro bioaccessibility and activity of Greek oregano (Origanum vulgare L. ssp. hirtum (link) Ietswaart) compounds as affected by nitrogen fertilization, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Journal of the Science of Food and Agriculture (2020), 100(6), 2410-2417, database is CAplus and MEDLINE.

Greek oregano is a culinary and medicinal herb native to the Mediterranean region; however nowadays it is cultivated in many regions all over the world. It is commonly used as a spice for flavoring food products and in various traditional medicine applications. This study investigated the effect of nitrogen fertilization at 0-150 kg N ha^-1 on the potential bioaccessibility and activity of Greek oregano compounds For this purpose the total phenolic content, rosmarinic acid content, and antioxidant activities of the raw material, as well as digested fractions, were determined Nitrogen fertilization had a neg. influence on the phenolic content and antioxidant activity of raw material; however, its effect on the potential bioaccessibility varied depending on the dose. The highest potential bioaccessibility and activity was determined for plants fertilized with 30 kg N ha^-1. For the gastric and intestinal phases of digestion, the potential bioaccessibility percentages were 39.5% and 29.6% for total phenolics, 53.1% and 11.2% for rosmarinic acid content, 45.2% and 44.4% for antiradical activity against 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 39.2% and 27.2% for antiradical activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 50.2% and 23.4% for reducing power, resp. The results showed that nitrogen fertilization is an important factor determining the in vitro bioaccessibility of Greek oregano compounds Furthermore, the nutraceutical potential of herbs, in term of the bioaccessibility of bioactive compounds, may be optimized during plant cultivation by applying an accurate nitrogen level.

Journal of the Science of Food and Agriculture published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C16H10O5, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kain, Dolly published the artcileMetabolic characterization, antioxidant capacity, and In vitro antiurolithiatic potential of Achillea millefolium L., Computed Properties of 30931-67-0, the publication is Journal of Young Pharmacists (2021), 13(3), 211-216, database is CAplus.

The current study investigated the antioxidant and antiurolithiatic potential of A. millefolium along with its metabolic characterization. A. millefolium has been collected at vegetative (V) and mature (Inflorescence (I) and Stem and Leaves (S+L)) stages and extracted in ethanol. Antioxidant potential has been determined by total phenolic content, total flavonoid content, ferric reducing antioxidant potential, total antioxidants through phosphomolybdate assay and free radical scavenging assays (1,1-diphenyl-2-picrylhydrazyl) and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid). In vitro antiurolithiatic activity is determined by turbidity changes in artificial urine, nucleation assay, and aggregation assay. Fourier transform-IR spectroscopy and gas chromatog.-mass spectrometry has been used to characterize the active metabolites of plant A. millefolium. Maximum antioxidant activity was observed in Inflorescence with values 76.58 mg of GAE/g of extract, 18.82 mg of RE/g of extract, 199.799 mg of AAE/g of extract and 327.95 mg of AAE/g of extract for TPC, TFC, FRAP and total antioxidants through phosphomolybdate assay resp. Maximum radical scavenging activity was also observed in inflorescence with 86.3% and 69.655 % inhibition against DPPH and ABTS free radicals at 1000μg/mL concentration resp. Maximum in vitro antiurolithiatic potential of plant A. millefolium observed in inflorescence i.e. 80 %, 41.84% and 63.41 % inhibition at 1000μg/mL concentration for turbidity changes in artificial urine method, nucleation assay and aggregation assay resp. FT- IR and GCMS of inflorescence of A. millefolium confirmed the presence of major functional groups and active metabolic compounds resp. Inflorescence of plant A. millefolium is an excellent source of natural antioxidants with significant antiurolithiatic potential.

Journal of Young Pharmacists published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Computed Properties of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhou, Bing published the artcileImpact of genotype, environment, and malting conditions on the antioxidant activity and phenolic content in US malting barley, HPLC of Formula: 30931-67-0, the publication is Fermentation (2020), 6(2), 48, database is CAplus.

The phenolic content and antioxidant potential of malting barley are important in brewing. The objective of our study was to investigate the effects of barley genotype, growing environment, and malting conditions on the total phenolic content and antioxidant activities of malting barley grown in North America. Eight barley cultivars grown at three locations over three years were used. For the malting study, a single barley cultivar, separated into different kernel size fractions, was germinated for various periods of time and then processed by kilning or freeze-drying. Total phenolic content (TPC) and some of the antioxidant activities, including DPPH, ABTS, and superoxide anion radical scavenging activities, reducing power, and iron (II) chelating activity, were significantly impacted by the barley genotype, growth environment, and their interactions. The TPC and most antioxidant activities were also influenced by malting conditions and were generally higher in the malted barleys of the thin kernel size fraction, four-day germination, and in samples processed by kilning, when compared to the plumper kernel size fractions, one and two days of germination, and freeze-dried samples, resp. There were interactions between malting parameters, and stepwise regression anal. was used to suggest the contribution of each parameter to the TPC and antioxidant activities.

Fermentation published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C17H19N3O7S, HPLC of Formula: 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Yuzugullu Karakus, Yonca published the artcileApplication of three-phase partitioning to the purification and characterization of polyphenol oxidase from antioxidant rosemary (Rosmarinus officinalis L.), Synthetic Route of 30931-67-0, the publication is International Journal of Food Engineering (2020), 16(11), 20200118, database is CAplus.

Polyphenol oxidase (PPO) has been purified from the rosemary plant (Rosmarinus officinalis L.) through three-phase partitioning (TPP) and has been biochem. characterized. The optimized TPP consisted of 50% (w/v) ammonium sulfate and equal volumes of crude extract and tert-butanol prepared at pH 6.5 and room temperature Using this system, PPO was purified 14-fold, with 230% recovery of activity from the middle phase. The partitioned enzyme had a mol. mass of 53 kDa. The highest enzyme activity was detected at 30 °C and pH 7.0 against catechol. In substrate specificity tests, the enzyme displayed activity towards catechol, 4-methylcatechol, caffeic acid, hydroquinone, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), pyrogallol, syringaldezine, and 3,4-dihydroxy-L-phenylalanine but no activity towards L-tyrosine. The enzyme was inhibited by the common PPO inhibitors; salicylhydroxamic acid (SHAM), cetyltrimethylammonium bromide (CTAB), polyvinylpyrrolidone (PVP), and the organic solvent DMSO (DMSO). Enzyme activity increased in the presence of the organic solvents acetone, ethanol, and methanol.

International Journal of Food Engineering published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C11H15NOS, Synthetic Route of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Gasior, Justyna published the artcileCarbohydrates profile, polyphenols content and antioxidative properties of beer worts produced with different dark malts varieties or roasted barley grains, COA of Formula: C18H24N6O6S4, the publication is Molecules (2020), 25(17), 3882, database is CAplus and MEDLINE.

The aim of this study was to assess the possibility of shaping properties of beers at the stage of brewing wort production with the use of various types of special malts (chocolate pale, chocolate dark, wheat chocolate, brown barley) and roasted barley grains. The carbohydrate profile, polyphenols content, antioxidant capacity, 5-hydroxymethylfurfural content, and the browning index level were analyzed. Statistical anal. showed significant differences in the values of the examined features between the samples. The sugars whose content was most affected by the addition of special malts were maltose and dextrins. The polyphenol content in worts with 10% of additive was 176.02-397.03 mg GAE/L, ferric reducing antioxidant power (FRAP) 1.32-2.07 mmol TE/L, and capacity to reduction radical generated from 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS•+) 1.46-2.70 mmol TE/L. Wort with 40% dark malt showed the highest content of polyphenolic compounds and antioxidant activity (FRAP and ABTS•+). The HMF content and the browning index value were higher for wort with the addition of darker-colored malts (EBC) and increased with increasing dark malt dose.

Molecules published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, COA of Formula: C18H24N6O6S4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhang, YanQing published the artcileFabrication and characterization of enzyme electrode for lactate fuel cell, Category: thiazole, the publication is Hwahak Konghak (2021), 59(3), 373-378, database is CAplus.

The study aimed to develop a high-power enzymic electrode for a wearable fuel cell that generates electricity utilizing lactate present in a sweat as fuel. Anode was fabricated by immobilizing lactate oxidase (LOx) on flexible carbon paper. As the lactate concentration in the electrolyte solution increased, the amount of current generated by catalysis of lactate oxidase increased. The immobilized LOx generated 1.5-times greater oxidation c.d. in the presence of gold nanoparticles than carbon paper only. Bilirubin oxidase (BOD)-immobilized cathode generated a larger amount of reduction current in the electrolyte saturated with oxygen than purged with nitrogen. A fuel cell composed of two electrodes was fabricated and cell voltage was measured under different discharge current. At the discharge c.d. of 66.7μA/cm², the cell voltage was 0.5±0.0 V leading to maximum cell power d. of 33.8±2.5μW/cm².

Hwahak Konghak published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C12H10O4S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kinkar, Eyad published the artcileThe multicopper oxidase of Mycobacterium tuberculosis (MmcO) exhibits ferroxidase activity and scavenges reactive oxygen species in activated THP-1 cells, Application of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is International Journal of Medical Microbiology (2019), 309(7), 151324, database is CAplus and MEDLINE.

The MmcO protein of Mycobacterium tuberculosis is a membrane-associated multicopper oxidase. Its natural substrate(s) and its role in pathogenesis are not well characterized. A recent report proposes that MmcO contributes to copper resistance in M. tuberculosis during infection. We have expressed and reconstituted the active enzyme from inclusion bodies in E. coli. MmcO exhibits maximal activity against the exptl. substrate 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) or ABTS, at pH 4. The enzyme also exhibits ferroxidase activity at pH 4. Most notable was the finding that MmcO is able to scavenge the reactive oxygen species (ROS) generated by the xanthine/xanthine oxidase enzyme system. This ROS scavenging activity of MmcO was also evident against ROS generated by THP-1 cells. We propose that MmcO protects M. tuberculosis during infection against ROS attack in addition to providing copper resistance to the pathogen.

International Journal of Medical Microbiology published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Application of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Vikram, V. published the artcileProtein profiling and isolation of bioactive hydrolysates with antioxidant activity from stem callus tissue of tinospora cordifolia (willd.) miers exposed to cyclodextrin, Application In Synthesis of 30931-67-0, the publication is International Journal of Pharmaceutical Sciences and Research (2021), 12(1), 524-535, database is CAplus.

This study is aimed to evaluate the effects of different concentrations of cyclodextrin, an auxin stabilizing agent, on callus growth from the stem explants of Tinospora cordifolia and to assess the antioxidant properties of the bioactive hydrolyzates of callus tissue using chymotrypsin, trypsin, pepsin, and papain. Cyclodextrin exerted a dose- and time-dependent effect on the callus growth. α-Chymotrypsin hydrolyzate showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH•) radical scavenging, while trypsin hydrolyzate exhibited the highest 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+) activity. Protein profiling of callus tissue revealed a few tissue-specific bands at 41, 30, 20, and 9 kDa with varying intensities. A growth medium containing sucrose has a specific impact on the expression of these polypeptides. Purification of 30 kDa polypeptide by Sephadex-G50 revealed distinct quant. differences to different concentrations of cyclodextrin. This study suggested that T.cordifolia callus tissue protein hydrolyzates exhibited antioxidant efficacy, leading to the development of a nutraceutical agent in promoting health.

International Journal of Pharmaceutical Sciences and Research published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C19H21N3O, Application In Synthesis of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Gaikwad, Adwait published the artcileHydrogen-Bonded, Mechanically Strong Nanofibers with Tunable Antioxidant Activity, Category: thiazole, the publication is ACS Applied Materials & Interfaces (2020), 12(9), 11026-11035, database is CAplus and MEDLINE.

We report on mech. strong, water-insoluble hydrogen-bonded nanofiber mats composed of a hydrophilic polymer and a natural polyphenol that exhibit prolonged antioxidant activity. The high performance of fibrous mats resulted from the formation of a network of hydrogen bonds between a low-mol.-weight polyphenol (tannic acid, TA) and a water-soluble polymer (polyvinylpyrrolidone, PVP) and could be precisely controlled by the TA-to-PVP ratio. Dramatic enhancement (5- to 10-fold) in tensile strength, toughness, and Young’s moduli of the PVP/TA fiber mats (as compared to those of pristine PVP fibers) was achieved at the maximum d. of hydrogen bonds, which occurred at ∼0.2-0.4 M fractions of TA. The formation of hydrogen bonds was confirmed by an increase in the glass-transition temperature of the polymer after binding with TA. When exposed to water, the fibers exhibited composition- and pH-dependent stabilities, with the TA-enriched fibers fully preserving their integrity in acidic and neutral media. Importantly, the fiber mats exhibited strong antioxidant activity with dual (burst and prolonged) activity profiles, which could be controlled via fiber composition, a feature useful for controlling radical-scavenging rates in environmental and biol. applications.

ACS Applied Materials & Interfaces published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica