With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344-72-9,Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
8.6 g of Boc-Citrulline was dissolved in 250 mL of DMF. The solution was added 7.2 mL of DIEA and 6.7 g of CDI. After stirred at r.t. for 30 min, the solution was added 5 g of ethyl-2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate (Matrix Scientific, Columbia S.C. USA). The reaction was quenched after additional 2 hours at r.t. by the addition of 25 mL of water. The mixture was diluted with 250 mL of EtOAc. The organic layer was washed with IN HC1, brine and worked up as described in General Procedure. Pure title compmmd 1A was obtained by purification on a fresh silica gel column eluted with 5% MeOH in DCM (5.6 g, yield 54%) (US 2010/0273843; incorporated by reference).
344-72-9, 344-72-9 Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate 67656, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; SPEROVIE BIOSCIENCES, INC.; IYER, Radhakrishnan, P.; MEHER, Geeta; SHERI, Anjaneyulu; ZHOU, Shenghua; CHALLA, Sreerupa; GIMI, Rayomand, H.; PADMANABHAN, Seetharamaiyer; CLEARY, Dillon; (194 pag.)WO2019/51488; (2019); A1;,
Thiazole | C3H3NS – PubChem
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