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The total synthesis of epothilone D with six-fold application in the intermediate stages of successive cyclopropanation – opening or cleavage of the three-membered ring was performed. These transformations underlie the new stereoselective method developed for coupling fragments C7-C 12 and C13-C21 in the target molecule.
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Reference:
Thiazole | C3H5119NS – PubChem,
Thiazole | chemical compound | Britannica