With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.824403-26-1,5-Bromo-2-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.
824403-26-1, To a solution of 5-bromo-2-chlorobenzo[d]thiazole (0.87 g, 3.5 mmol) in ethanol (12 mL) was added isopropylamine solution (1.5 mL) and the mixture was heated for 60 minutes using a Biotage microwave oven at 100C. The reaction mixture was cooled to room temperature. The solvent was removed, the crude product was dissolved in dichlormethane (150 mL) and washed with 1 M NaOH solution, water and brine and dried over Na2S04. The solvent was removed under reduced pressure to give a crude product, which was purified on a silica gel column using an EtOAc and heptane gradient (20/80 => 50/50) to afford the title compound as a solid (0.75 g, 79 %). (0516) 1H-NMR (400 MHz, Chloroform-d) d = 7.67 (d, J = 1.9 Hz, 1 H), 7.43 (d, J = 8.5 Hz, 1 H), 7.19 (dd, J = 8.3, 1.9 Hz, 1 H), 5.47 (s, 1 H), 4.04 – 3.79 (m, 1 H), 1.34 (d, J = 6.5 Hz, 6H).
As the paragraph descriping shows that 824403-26-1 is playing an increasingly important role.
Reference：
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (220 pag.)WO2019/134978; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica