Some new Schiff base derivatives derived from vanillin as possible fungicides was written by Dash, B.;Patra, M.;Mahapatra, P. K.. And the article was included in Journal of the Indian Chemical Society in 1983.Reference of 6318-74-7 This article mentions the following:
Schiff bases I (R, R1 = H, Ph, 4-MeC6H4, 4-ClC6H4, 4-BrC6H4, 4-MeOC6H4, naphthyl; R2 = H) derived from 4-substituted and 4,5-disubstituted-2-amino thiazoles and vanillin were prepared Cycloaddition of I with HSCH2CO2H yielded thiazolidones II. Condensation of the Schiff bases with ClCH2COCl and subsequent reaction with piperidine and morpholine yielded corresponding acetoxy derivatives I (R2 = morpholinoacetyl, piperidinoacetyl). The compounds were characterized by elemental anal. and IR spectra and were screened for fungicidal activity. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Reference of 6318-74-7).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Reference of 6318-74-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica