Reactions of 2-aminobenzothiazoles with ethylene chlorohydrin. Molecular and crystal structure of bis[3-(2-hydroxyethyl)benzothiazol-2-ylidene]ammonium chloride was written by Makhmudov, M. K.;Ambartsumova, R. F.;Tashkhodzhaev, B.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1996.Synthetic Route of C13H10N2S This article mentions the following:
2-Aminobenzothiazoles I (R = H, Me, Et, CH2CH2OH, Ph) reacted with ClCH2CH2OH to give mainly 3-(2-chloroethyl)benzothiazolinone (II; R1 = Cl, X = O). In the case of I (R = H), the imine II (R1 = OH, X = NH) and the title ammonium salt (III) were also obtained. Reaction of I (R = H) with II (R1 = Cl, X = O) gave IV. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Synthetic Route of C13H10N2S).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Synthetic Route of C13H10N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica