62266-82-4,62266-82-4, 6-Bromobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a cooed (0 C) soufion of 6-bromobenzo[d]thazo-2(3H)-one (lOg, 4.4 mmo) fl THF (8.9mL) was added 60 wt% sodium hydride fl mnera oH (209 mg, 5.2 mmofl portonwse. After 20 minutes, 2-(trmethys y)ethoxymethy chorde (0.77 mL, 4.4 mmo) was added dropwse. The resuWng yeflow souUon was aflowed to warm to rt and sUrred for a tota of 2h. Brne was added and the nixture was extracted wfth EtOAc (x3). The combned organic extracts were dried (Na2504), fHtered and concentrated in vacuo. Purflcafion(FCC, SO2; 0-30% EtOAc/hexanes) afforded the desired product as a whte sohd (1.2 g,77% yed). 1H NMR (400 MHz. CDC3) S 8.10-.- 7.99 (m, I H), 7.64 (ddd, J = 7.7, 2.9, 1.5Hz, 1 H), 7.38 (dd, J = 83, 2.8 Hz, 1 H), 5.42 (d, J = 2.7 Hz, 2H), 363 (t, J = 7.8 Hz, 2H),0.92 (t, J = 7.8 Hz, 2H), 0.00 (5, 9H).
As the paragraph descriping shows that 62266-82-4 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; RAVULA, Suchitra; SWANSON, Devin M.; SAVALL, Bradley M.; AMERIKS, Michael K.; (250 pag.)WO2016/176449; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica