Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-32-3,Thiazole-5-carboxyaldehyde,as a common compound, the synthetic route is as follows.

4-[(3-Carbamoylphenyl)(piperidin-4-yliden e)methyl]-N, N-dimethylbenzamide (40 mg, 11 mmcl) and1,3-thiazole-5-carbaldehyde (13.7 mg, 0.12 mmcl) were dissolved in dichloroethane (1.5 mL). Acetic acid (6.3 pL, 0.11 mmol) was added and the reaction was stirred for 10 minutes at room temperature before NaBH(OAc)3 (37.3 mg, 0.18 mmol) was added. The reaction mixture was stirred at room temperature for 2 days. Methylene chloride (1 mL) was added and the mixture waswashed with water (1 mL). The water phase was extracted with methylene chloride (1 mL x 3). The combined organic phases were dried with Na2SO4, filtered and evaporated. The crude product was purified by preparative HPLC (25 to 65% CH3CN in 50 mM NH4HCO3(aq)) to give the title compound (8.2 mg, 16% yield) as a white solid. MS ESI m/z 461 [M+H]., 1003-32-3

As the paragraph descriping shows that 1003-32-3 is playing an increasingly important role.

Reference£º
Patent; PHARMNOVO AB; VON MENTZER, Bengt; STARKE, Ingemar; BRANDT, Peter; (20 pag.)WO2016/99393; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

62266-82-4,62266-82-4, 6-Bromobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a cooed (0 C) soufion of 6-bromobenzo[d]thazo-2(3H)-one (lOg, 4.4 mmo) fl THF (8.9mL) was added 60 wt% sodium hydride fl mnera oH (209 mg, 5.2 mmofl portonwse. After 20 minutes, 2-(trmethys y)ethoxymethy chorde (0.77 mL, 4.4 mmo) was added dropwse. The resuWng yeflow souUon was aflowed to warm to rt and sUrred for a tota of 2h. Brne was added and the nixture was extracted wfth EtOAc (x3). The combned organic extracts were dried (Na2504), fHtered and concentrated in vacuo. Purflcafion(FCC, SO2; 0-30% EtOAc/hexanes) afforded the desired product as a whte sohd (1.2 g,77% yed). 1H NMR (400 MHz. CDC3) S 8.10-.- 7.99 (m, I H), 7.64 (ddd, J = 7.7, 2.9, 1.5Hz, 1 H), 7.38 (dd, J = 83, 2.8 Hz, 1 H), 5.42 (d, J = 2.7 Hz, 2H), 363 (t, J = 7.8 Hz, 2H),0.92 (t, J = 7.8 Hz, 2H), 0.00 (5, 9H).

As the paragraph descriping shows that 62266-82-4 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; RAVULA, Suchitra; SWANSON, Devin M.; SAVALL, Bradley M.; AMERIKS, Michael K.; (250 pag.)WO2016/176449; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.344-72-9,Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

8.6 g of Boc-Citrulline was dissolved in 250 mL of DMF. The solution was added 7.2 mL of DIEA and 6.7 g of CDI. After stirred at r.t. for 30 min, the solution was added 5 g of ethyl-2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate (Matrix Scientific, Columbia S.C. USA). The reaction was quenched after additional 2 hours at r.t. by the addition of 25 mL of water. The mixture was diluted with 250 mL of EtOAc. The organic layer was washed with IN HC1, brine and worked up as described in General Procedure. Pure title compmmd 1A was obtained by purification on a fresh silica gel column eluted with 5% MeOH in DCM (5.6 g, yield 54%) (US 2010/0273843; incorporated by reference).

344-72-9, 344-72-9 Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate 67656, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; SPEROVIE BIOSCIENCES, INC.; IYER, Radhakrishnan, P.; MEHER, Geeta; SHERI, Anjaneyulu; ZHOU, Shenghua; CHALLA, Sreerupa; GIMI, Rayomand, H.; PADMANABHAN, Seetharamaiyer; CLEARY, Dillon; (194 pag.)WO2019/51488; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

777-12-8, 6-(Trifluoromethyl)benzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

777-12-8, 8.25 ml tert-butyl nitrite were added to a solution of 7.40 g copper (II) chloride in 120 ml acetonitrile. The reaction mixture was stirred ten minutes at room temperature. Then a solution of 10.0 g 2-Amino-6-(trifluoromethyl)benzonitrile were added. Then 100 ml 1 N HCI were added to the cooled reaction mixture. The reaction mixture was extracted five times with portions of 50 ml ethyl acetate. The combined organic layers were washed with water and the dried over MgSO4. The solvent was removed in vacuo to obtain 9.79 g crude 2-Chloro-6-trifluoromethyl-benzothiazole as a red oil which solidifies upon standing. This material was used without further purification. C8H3CIF3NS (237.63), MS(GC): 237.0 (M+H+), Rf(n-heptane :ethyl acetate = 1 :1) = 0.72 .

As the paragraph descriping shows that 777-12-8 is playing an increasingly important role.

Reference£º
Patent; SANOFI-AVENTIS DEUTSCHLAND GMBH; WO2007/39176; (2007); A1;,
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6436-59-5, Ethyl 2-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6436-59-5, To a solution of 2-methyl-4-thiazolecarboxylic acid ethyl ester (3 g, 17.52 mmol) in MeCN (30 ml_), 1 -bromopyrrolidine-2,5-dione (6.24 g, 35.04 mmol) was added. Reaction was heated to reflux and stirred at the same temperature for 20 hrs. Then it was cooled down to RT and then cooled to 0 C. ss NaHCC>3 (aq) was added and mixture was stirred for 15 min at the same temperature. MeCN was removed under reduced pressure and DCM was added. Aqueous layer was extracted several times with DCM. Combined organic layers were dried and concentrated under reduced pressure. Crude was purified by FC on silica gel (eluent: Cy/EtOAc from 100:0 to 70:30) to afford ethyl 5-bromo-2-methyl-1 ,3- thiazole-4-carboxylate (p17, 2.95 g, y= 67%) as a pale orange solid. MS (mlz): 249.8 [M]+.

6436-59-5 Ethyl 2-methylthiazole-4-carboxylate 293353, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; CHRONOS THERAPEUTICS LIMITED; MICHELI, Fabrizio; CREMONESI, Susanna; SEMERARO, Teresa; TARSI, Luca; GIBSON, Karl Richard; (116 pag.)WO2019/81939; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

533-30-2,533-30-2, 6-Aminobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00405] Step 2: A mixture of 6-chloro-4-((lS,2S)-2,3-dihydroxy-l- phenylpropylamino)nicotinonitrile (0.108 g, 0.356 mmol), benzo[d]thiazol-6-amine (0.187 g, 1.244 mmol) and NMP (1.422 mL) was stirred at 150 ¡ãC for 1 hour in a microwave reactor. The vessel was cooled to room temperature, diluted with water and filtered. Following drying on a buchner funnel, 6-(benzo[d]thiazol-6-ylamino)-4- ((lS,2S)-2,3-dihydroxy-l-phenylpropylamino)nicotinonitrile (0.122 g, 0.292 mmol, 82 percent yield) was collected as a yellowish solid. LC-MS (m/z, M+l= 418), Waters sunfire 4.6x50mm C18 5um 4 min/1 min hold time 0-100percent (A-B) A=10percent MeOH-90percent water – 0.1percentTFA, B=90percent MeOH-10percent water – 0.1percentTFA RT= 2.06.

The synthetic route of 533-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; DODD, Dharmpal, S.; MUSSARI, Christopher, P.; BHIDE, Rajeev, S.; NAIR, Satheesh Kesavan; PAIDI, Venkatram Reddy; KUMAR, Sreekantha Ratna; BANERJEE, Abhisek; SISTLA, Ramesh; PITTS, William, J.; HYNES, John; WO2013/106614; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

41731-39-9, 2-Bromo-4-(trifluoromethyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of oxetan-3-yl 4-(1-(phenylsulfonyl)-2-(tributylstannyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperazine-1-carboxylate (250 mg, 342 mupiiotaomicron), 2-bromo-4- (trifluoromethyl)thiazole (120 mg, 513 muiotaetaomicron), Cul (65 mg, 342 mmol), and Pd(PPh3)4 (197 mg, 171 muetaiotaomicron) in toluene (10 mL) was degassed with N2, and then stirred at 100C for 16 h under N2. The mixture was cooled to room temperature and concentrated. The residue was directly purified by silica gel chromatography (ethyl acetaterpetroleum ether = 3: 10) to give the title product (70 mg, yield 35%) as a light yellow solid. MS (ES+) C25H22F3N5O5S2 requires: 593, found: 594 [M+H]+.

41731-39-9, 41731-39-9 2-Bromo-4-(trifluoromethyl)thiazole 23149887, athiazole compound, is more and more widely used in various.

Reference£º
Patent; BLUEPRINT MEDICINES CORPORATION; BRUBAKER, Jason D.; FLEMING, Paul E.; KIM, Joseph L.; WILLIAMS, Brett; HODOUS, Brian L.; (238 pag.)WO2019/79649; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38205-60-6,1-(2,4-Dimethylthiazol-5-yl)ethanone,as a common compound, the synthetic route is as follows.

EXAMPLE 23 1-(2,4-Dimethyl-5-thiazolyl)-1-(3-pyridyl)ethanol 5-Acetyl-2,4-dimethylthiazole (2.5 g) in dry diethylether (10 ml) was added dropwise to a stirred solution of 3-lithiopyridine (from 3.5 g 3-bromopyridine) in diethylether at -70 C. After 3 hours the mixture was allowed to warm to room temperature. After a further 1 hour, aqueous sodium hydrogen carbonate was added and the organic layer was separated. The aqueous layer was extracted with diethylether. The material obtained from the combined organic layers was purified by flash chromatography to give the title compound, m.p. 107.5-109 C. 13 C Nmr (CDCl3) 16.3, 18.7, 32.7, 71.9, 123.1, 133.5, 137.9, 142.4, 146.9, 148.0 and 162.2 ppm.

38205-60-6, As the paragraph descriping shows that 38205-60-6 is playing an increasingly important role.

Reference£º
Patent; Astra Aktiebolag; US5607956; (1997); A;,
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Thiazole | chemical compound | Britannica

72850-52-3, Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

72850-52-3, EXAMPLE 49 STR65 Ethyl 2[(diphenylmethyl)amino]-4-(trifluoromethyl)-5thiazolecarboxylate A reaction vessel was charged with 120 ml of toluene and 11.0 g (42.4 mmol) of ethyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate (prepared as described in U.S. Pat. No. 4,199,506). Then, 15.5 g (86 mmol) of aminodiphenylmethane was added in one portion. The resulting yellowish-orange solution was refluxed under nitrogen for 9 days. Then, solvent was removed from the mixture under reduced pressure to yield a yellowish-orange solid material, which was flash chromatographed (~38 ml/min) on silica gel using 10% ethyl acetate in hexane solvent. There was obtained 13.2 g of a thick yellow oil which solidified upon standing to a yellow solid product (m.p.=92-95 C.) identified in Table I.

As the paragraph descriping shows that 72850-52-3 is playing an increasingly important role.

Reference£º
Patent; Monsanto Company; US5000775; (1991); A;,
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Thiazole | chemical compound | Britannica

1024583-33-2, Methyl 2-bromobenzo[d]thiazole-6-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-((((1R,3s,5S)-9-azabicyclo[3.3.1]decan-3-yl)oxy)methyl)-5-cyclopropyl-3-(2,6 -dichlorophenyl)isoxazole trifluoroacetate (500 mg, crude), methyl 2-bromobenzo[d]thiazole-6-carboxylate(272 mg, 1.0 mmol) and cesium carbonate (1.0 g, 3 mmol of) was added to the DMA (5 mL), the reaction microwave 120 0.5 hours, and pouredinto water (20mL), filtered (filter cake was purified by silica gel column chromatography in dichloromethane: methanol = 20: 1) to give the desired product ( 200 mg,two-step yield 49.2%).

1024583-33-2, The synthetic route of 1024583-33-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hainan Xuanzhu Pharmaceutical Technology Co., Ltd.; Fang Wenkui; Chen Bo; (66 pag.)CN109265471; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica