Tag: 200-300

Lanthanide-catalyzed cyclocarbonylation and cyclothiocarbonylation: a facile synthesis of benzannulated 1,3-diheteroatom five- and six-membered heterocycles was written by Jing, Yu Feng;Liu, Rui Ting;Lin, Yang Hui;Zhou, Xi Geng. And the article was included in Science China: Chemistry in 2014.HPLC of Formula: 1843-21-6 This article mentions the following:

La[N(SiMe₃)₂]₃ proved to be an efficient catalytic system for the cyclocarbonylation of 1,2-disubstituted benzenes with isocyanates. Aryl/alkyl isocyanates were reacted with o-phenylenediamine, o-aminophenol, o-aminothiophenol, catechols and anilines ortho-substituted by CH₂NH₂ and CONH₂ to form the corresponding benzimidazolones, benzoxazolones, benzothiazolones, benzodioxolones, 3,4-dihydroquinazolin-2(1H)-one and quinazolinediones resp. This methodol. was also applicable for the preparation of the corresponding thio analogs starting from aryl/alkyl isothiocyanates or CS₂ in good to excellent yields. Based on the results of experiments performed using an o-aminobenzamido dianion lanthanide complex, a general mechanism involving the tandem reaction of two lanthanide-ligand bonds was proposed. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6HPLC of Formula: 1843-21-6).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.HPLC of Formula: 1843-21-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Determination of acetazolamide in biological fluids by high-performance liquid chromatography was written by Gal, Joseph;Ellis, Philip P.;Rendi, Maris. And the article was included in Current Eye Research in 1981.Related Products of 69812-29-9 This article mentions the following:

A high-performance liquid chromatog. (HPLC) assay for acetazolamide (I) [59-66-5] is presented. A 100-μL sample is mixed with an aliquot of the internal standard solution and the mixture, buffered at pH 4.5, is extracted with Et acetate. The extract is evaporated to dryness and the residue is analyzed by HPLC, using a reverse-phase octadecylsilane column. The wavelength of the detection is 254 nm. The relative standard deviation in the within-day anal. of replicate 10-μg/mL acetazolamide samples in human blood plasma was 6.5%, whereas the between-day relative standard deviation was 7.1%. The procedure was developed for the 1-25 μg/mL acetazolamide concentration range. The internal standard used is similar in chem. structure to acetazolamide and can be readily prepared in one step from a com. available precursor. In addition to blood serum or plasma, the assay can also use aqueous and vitreous human samples. Theophylline and acetaminophen interfere in the assay. The technique was used to determine the concentration of acetazolamide in the blood serum of human volunteers after an oral dose of the drug, and in the aqueous and vitreous humors of rabbits after an i.v. dose of acetazolamide. In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9Related Products of 69812-29-9).

2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Related Products of 69812-29-9

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

1,10-phenanthroline-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates in water was written by Zhang, Wu;Yue, Yun;Yu, Dan;Song, Lei;Xu, Yang-Yang;Tian, Yu-Jie;Guo, Yu-Jun. And the article was included in Advanced Synthesis & Catalysis in 2012.Safety of N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

The 1,10-phenanthroline-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates in water was carried out, which provides an environmentally benign, efficient and simple route for the preparation of 2-aminobenzothiazoles. The present tandem process shows broad substrate scope in the absence of transition metals and phase-transfer catalysts. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Safety of N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Safety of N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

DDQ-promoted C-S bond formation: synthesis of 2-aminobenzothiazole derivatives under transition-metal-, ligand-, and base-free conditions was written by Wang, Rui;Yang, Wen-juan;Yue, Liang;Pan, Wei;Zeng, Hong-yao. And the article was included in Synlett in 2012.Recommanded Product: N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

A transition-metal-free method for the intramol. S-arylation of o-halobenzothioureas via DDQ-mediated leading to the 2-aminobenzothiazole derivatives, e.g., I (R = H, Me, MeO, F; R² = H, Me, MeO, Cl, Br), is reported. The reactions are performed at room temperature under ligand- and base-free conditions with good to excellent yields. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Recommanded Product: N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Recommanded Product: N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents was written by Kamal, Ahmed;Swapna, P.;Shetti, Rajesh V. C. R. N. C.;Shaik, Anver Basha;Narasimha Rao, M. P.;Gupta, Soma. And the article was included in European Journal of Medicinal Chemistry in 2013.HPLC of Formula: 69812-29-9 This article mentions the following:

A number of linezolid-like oxazolidino-sulfonamides were designed and synthesized with a view to develop antimicrobial agents with improved properties. Most of the synthesized compounds showed good to moderate activity against a panel of standard Gram-pos. and Gram-neg. bacteria and fungal strains. The compounds I (X = O, S) exhibited significant activity, with a MIC value of 2.0-6.0 μg/mL against a panel of Gram-pos. and Gram-neg. bacteria. These compounds also showed activity against Candida albicans, with a MIC value of 4.0 μg/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented. In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9HPLC of Formula: 69812-29-9).

2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.HPLC of Formula: 69812-29-9

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Oxidation of thiourea derivatives in glacial acetic acid. I was written by Klatsmanyi-Gabor, Piroska;Meisel, Tibor;Erdey, Laszlo. And the article was included in Acta Chimica Academiae Scientiarum Hungaricae in 1964.Application In Synthesis of N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

The mechanism of the activity of the redox indicator [4-(4-MeOC₆H₄NH)-C₆H₄NH]₂CS in AcOH medium was elucidated. An investigation of the oxidation of thiourea compounds by Br in AcOH and in AcOH containing NaOH revealed that aryl and diaryl thiourea derivatives were converted into benzothiazole compounds by ring closure, while similar derivatives containing non-aromatic substituents yielded di-sulfide compounds In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Application In Synthesis of N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Application In Synthesis of N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mass spectra of derivatives of 2-phenylaminobenzothiazole and its isomers was written by Rashkes, Ya. V.;Ambartsumova, R. F.;Saprykina, V. A.;Rozhkova, N. K.. And the article was included in Zhurnal Organicheskoi Khimii in 1981.COA of Formula: C13H10N2S This article mentions the following:

The mass spectra of I (R = H, Me, MeO, Cl, NO₂; R¹, R², R³ = H, Me), II (R-R³ = H, Me), and III (R-R³ = H, Me) were recorded. Formation of [M-R]⁺ ions was accompanied by cyclization. Loss of R¹NC and R¹NCS fragments was prominent in II. III exhibited rearrangement processes. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6COA of Formula: C13H10N2S).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.COA of Formula: C13H10N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Positive and negative ion spectra of 2-aminobenzothiazole derivatives was written by Claude, S.;Duc, L.;Tabacchi, R.. And the article was included in International Journal of Mass Spectrometry and Ion Physics in 1983.Quality Control of N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:

The mass spectral fragmentations under electron impact of N-phenyl-, N-(o-tolyl)-, 4-methyl-N-phenyl-, and 4-methyl-N-(o-tolyl)-2-aminobenzothiazoles have been investigated. The pos. and neg. ion spectra yielded complementary information. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Quality Control of N-Phenylbenzo[d]thiazol-2-amine).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Quality Control of N-Phenylbenzo[d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Silver-Nitrate-Catalyzed N-Arylation of Amines and O-Arylations of Phenols and Alcohols was written by Das, Rima;Mandal, Mrinmay;Chakraborty, Debashis. And the article was included in Asian Journal of Organic Chemistry in 2013.Recommanded Product: 1843-21-6 This article mentions the following:

An efficient and general protocol for an intermol. carbon-nitrogen cross-coupling of amines, alcs., and phenols with halides was developed and the synthesis of the target compounds was achieved using silver nitrate (AgNO₃) as a catalyst and N,N-dimethylethylenediamine (N,N-DMEDA) as a ligand and potassium tert-butoxide (KOtBu) as a base under a nitrogen atm. A number of primary, secondary, and heterocyclic amines were coupled with various aryl iodides to give N-aryl derivatives in good to excellent yield. Along with this, several substituted phenols as well as alcs. were coupled with various halides under the same reactions condition to give O-arylated compounds The title compounds thus formed included N-phenylbenzenamine, 1-phenyl-1H-imidazole, 4-phenylmorpholine, 1-phenyl-2,3-indoledione, N-phenylbenzamide, (4-methylphenyl)phenyl ether, (phenoxy)benzene derivatives, methoxybenzene, aryl ethers. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Recommanded Product: 1843-21-6).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Recommanded Product: 1843-21-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Reactions of 2-aminobenzothiazoles with ethylene chlorohydrin. Molecular and crystal structure of bis[3-(2-hydroxyethyl)benzothiazol-2-ylidene]ammonium chloride was written by Makhmudov, M. K.;Ambartsumova, R. F.;Tashkhodzhaev, B.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1996.Synthetic Route of C13H10N2S This article mentions the following:

2-Aminobenzothiazoles I (R = H, Me, Et, CH₂CH₂OH, Ph) reacted with ClCH₂CH₂OH to give mainly 3-(2-chloroethyl)benzothiazolinone (II; R¹ = Cl, X = O). In the case of I (R = H), the imine II (R¹ = OH, X = NH) and the title ammonium salt (III) were also obtained. Reaction of I (R = H) with II (R¹ = Cl, X = O) gave IV. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Synthetic Route of C13H10N2S).

N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Synthetic Route of C13H10N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica