Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

To a solution of commercially available 2-amino-6-bromobenzothiazole (3.0 g, 13.0 mmol) in THF (30 mL) was added acetic anhydride (4 mL, 42.3 mmol). The solution was stirred at room temperature for 2 days. THF was removedin vacuoand the residue was recrystallized from hot EtOAc to giveN-(6-bromobenzo[d]thiazol-2-yl)acetamide (2.5 g, 71%).

15864-32-1, As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Article; Pecchi, Sabina; Ni, Zhi-Jie; Han, Wooseok; Smith, Aaron; Lan, Jiong; Burger, Matthew; Merritt, Hanne; Wiesmann, Marion; Chan, John; Kaufman, Susan; Knapp, Mark S.; Janssen, Johanna; Huh, Kay; Voliva, Charles F.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 16; (2013); p. 4652 – 4656;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-38-6, 2-Chloro-5-nitrobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3622-38-6, o a solution of 2-chloro-5-nitrobenzo[d]thiazole (2.18 g, 10.2 mmol) in EtOH:acetic acid 91 :9 (102 mL) iron powder (5.70 g, 102 mmol) was carefully added. The mixture was refluxed for 1 .5 h before it was filtered. The filtrate was concentrated to about one third of the volume and the pH of the solution was adjusted to pH 8 by adding 10percent aq. NaOH solution. The mixture was extracted with EA (150 mL). The organic extract was washed with brine, dried over Na2S04, filtered and concentrated. The crude product was suspended in EtOH (4 mL), filtered, washed with additional EtOH (0.5 mL) and dried to give the title compound (1 .55 g) as a solid; LC-MS: tR= 0.78 min; [M+H]+= 185.03;1H NMR (400 MHz, D6-DMSO) delta: 7.65 (d, J = 8.7 Hz, 1 H), 7.06 (d, J = 1 .9 Hz, 1 H), 6.79 (dd, J, = 2.0 Hz, J2= 8.7 Hz, 1 H), 5.43 (s, 2 H).

3622-38-6 2-Chloro-5-nitrobenzo[d]thiazole 11413249, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOLLI, Martin; BOSS, Christoph; RICHARD-BILDSTEIN, Sylvia; SIEBER, Patrick; (95 pag.)WO2016/207785; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.824403-26-1,5-Bromo-2-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

824403-26-1, To a solution of 5-bromo-2-chlorobenzo[d]thiazole (0.87 g, 3.5 mmol) in ethanol (12 mL) was added isopropylamine solution (1.5 mL) and the mixture was heated for 60 minutes using a Biotage microwave oven at 100C. The reaction mixture was cooled to room temperature. The solvent was removed, the crude product was dissolved in dichlormethane (150 mL) and washed with 1 M NaOH solution, water and brine and dried over Na2S04. The solvent was removed under reduced pressure to give a crude product, which was purified on a silica gel column using an EtOAc and heptane gradient (20/80 => 50/50) to afford the title compound as a solid (0.75 g, 79 %). (0516) 1H-NMR (400 MHz, Chloroform-d) d = 7.67 (d, J = 1.9 Hz, 1 H), 7.43 (d, J = 8.5 Hz, 1 H), 7.19 (dd, J = 8.3, 1.9 Hz, 1 H), 5.47 (s, 1 H), 4.04 – 3.79 (m, 1 H), 1.34 (d, J = 6.5 Hz, 6H).

As the paragraph descriping shows that 824403-26-1 is playing an increasingly important role.

Reference：
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (220 pag.)WO2019/134978; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-bromo-6- methoxybenzo[d]thiazole (0.90 g; 3.7 mmol) was dissolved in CH2CI2 (50 mL). BBr3 (1M in CH2C12, 16 mL, 16 mmol) was added slowly. White precipitate formed immediately. After overnight, HPLC showed complete conversion. Excess CH2CI2 (200 mL) and brine (100 mL) were added. White precipitate formed immediately. The mixture was stirred at RT for 2 hours, until most solid dissolved. The organic layer was separated, and aqueous layer extracted with 2 x 100 mL CH2CI2. The combined organic solution was dried over MgS04. The solvent was removed to afford 0.71 g of product. Yield 83%., 2941-58-4

As the paragraph descriping shows that 2941-58-4 is playing an increasingly important role.

Reference：
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; CAI, Lisheng; PIKE, Victor W.; WO2013/40183; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-38-6, 2-Chloro-5-nitrobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 62 In 7.4 ml of tetrahydrofuran was dissolved 160 mg of 2-chloro-5-nitro-1,3-benzothiazole, and thereto was added 1.86 ml of a 1M dimethylamine tetrahydrofuran solution, followed by 16.5 hours of stirring. Water was added to the reaction solution and the organic layer was extracted with ethyl acetate. After the organic layer was dried over anhydrous sodium sulfate, the solvent was removed by evaporation. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate) to obtain 173 mg of N,N-dimethyl-5-nitro-1,3-benzothiazol-2-amine as a yellow solid.

3622-38-6, The synthetic route of 3622-38-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Astellas Pharma Inc.; EP1632477; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Bromobenzo[d]thiazol-2-amine (2.3 g, 10.0 mmol) was suspended in dichloromethane (30 ml), and then 4-dimethylaminopyridine (1.3 g, 11.5 mmol) was added. The mixture was cooled in an ice-water bath under nitrogen, and acetic anhydride (1.0 ml, 11.5 mmol) was added. The resulting mixture was allowed to slowly warm to room temperature while being stirred overnight under nitrogen. Then hydrochloric acid (10%, 10 ml) was added and 5b (2.3 g, 85%) was obtained by filtration as white solid. Mp: 217.0-218.0 C; 1H NMR (DMSO-d6): delta 12.46 (s, 1H, NH), 8.24 (s, 1H, Ar-H), 7.67 (d, J = 7.2 Hz, 1H, Ar-H), 7.57 (d, J = 6.8 Hz, 1H, Ar-H), 2.21 (s, 3H, CH3). ESI-HRMS m/z: calcd for C9H7BrN2NaOS [M+Na]+: 292.9360; found 292.9360., 15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Li, Huan; Wang, Xiao-Meng; Wang, Juan; Shao, Teng; Li, Yi-Ping; Mei, Qi-Bing; Lu, She-Min; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 22; 14; (2014); p. 3739 – 3748;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30132-15-1,2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid,as a common compound, the synthetic route is as follows.

B. To prepare the intermediate methyl (2-amino-benzothiazol-6-yl)acetate, 2 mL concentrated H2SO4 was added dropwise to a solution of (2-amino-1,3-benzothiazol-6-yl)acetic acid (7.89 g, 37.9 mmol) in 200 mL methanol and the reaction mixture was heated at 50 C. for 90 minutes. After evaporation of most of the methanol, dichloromethane (150 mL) was added and the mixture was neutralized with saturated NaHCO3 solution. The aqueous phase was extracted with dichloromethane. The organic extracts were combined, dried over MgSO4, and concentrated to give the product as a yellow solid (6.51 g, 77%). 1H NMR (DMSO-d6) delta 7.54 (s, 1H), 7.44 (br, 2H), 7.27 (d, 1H), 7.09 (d, 1H), 3.66 (s, 2H), 3.61 (s, 3H); LC-MS: ESI 223 (M+H)+., 30132-15-1

30132-15-1 2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid 757163, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Bhagwat, Shripad; Chao, Qi; Grotzfeld, Robert M.; Patel, Hitesh K.; Sprankle, Kelly G.; US2007/232604; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 12-(5-Bromo-thiazol-4-yl)-5-methyl- 1 H-benzoimidazole A solution of 5-bromo-thiazole-4-carboxylic acid (1.37 g, 6.59 mmol, commercially available from Combi-blocks), diisopropylethylamine (1.49 mL, 8.57 mmol), 4-methyl-beiizene-1,2- diamine (0.88 g, 7.25 mmol) in DMF (11 mL) at room temperature was treated with TBTU (2.75 g, 8.57 mmol) and the mixture stirred at room temperature for 18 h. The solvents were thenevaporated under vacuum and the residue partitioned between ethyl acetate and saturated solution of sodium bicarbonate, the organics were collected and dried with magnesium sulfate and then concentrated under vacuum. The crude mixture was dissolved in acetic acid (12 mL), transferred to microwave vial and the mixture was heated at 150 C in a microwave reactor for 1.5 h. After solvent evaporation, the residue was dissolved in dichioromethane, washed with saturated solution of sodium bicarbonate, dried with magnesium sulfate and concentrated under vacuum to yield 2-(5-bromo-thiazol-4-yl)-5-methyl-1H-benzoimidazole (1.93 g, crude,quantitative yield for two steps) as a beige solid that was used into the next step without further purification. ?H NMR (CHLOROFORM-d) 3: 8.82 (s, 1H), 7.64 (d, J = 7.9 Hz, iH), 7.47 (s, 1H), 7.15 (d, J = 8.3 Hz, 1H), 2.50 (s, 3H); LCMS (El/Cl) m/z: 293.9, 295.9 [M + H]., 103878-58-6

The synthetic route of 103878-58-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BHAGIRATH, Niala; DOMINIQUE, Romyr; KENNEDY-SMITH, Joshua; LUCAS, Matthew C.; PADILLA, Fernando; WO2014/64134; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2941-58-4,2-Bromo-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

2-Bromo-6-methoxybenzo [d] thiazole (555 mg, 2.28 mmol) was dissolved in methylene chloride (10 mL) at room temperature under an argon atmosphere. To the resulting solution, 1 M boron tribromide methylene chloride solution (4 mL) was added at room temperature. The resulting mixture was stirred under an argon atmosphere at room temperature for 7 hours.The reaction mixture was added to ice water and then extracted with chloroform (3 × 30 mL). The combined organic layer was dried over anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (silica gel 80 g; hexane: ethyl acetate (3: 1)) to give 2-bromobenzo [d] thiazol-6-ol (521 mg, yield 99 %) As a brown solid. The measured physical properties of the product are as follows., 2941-58-4

2941-58-4 2-Bromo-6-methoxybenzothiazole 11218765, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; KEIO UNIVERSITY; SAITOH, TSUYOSHI; NISHIYAMA, SHIGERU; IOKA, SHUJI; MAKI, SHOJIRO; NIWA, HARUKI; (19 pag.)JP6095208; (2017); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

96929-05-4, Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a. Tert-butyl N-[[4-(hydrazinecarbonyl)thiazol-2-yl]methyl]carbamate To a stirred solution of ethyl 2-(((tert-butoxycarbonyl) amino) methyl) thiazole-4-carboxylate (500 mg, 1.74 mmol) in dioxane (10 mL) was added hydrazine hydrate (3 mL) at room temperature and stirred for 3 h. The reaction mixture was diluted with water (30 mL), extracted with EtOAc (2 x 60 mL) and combined organic layer was dried, filtered and evaporated affording a pale yellow solid (520 mg, crude). M/z 273.1 (M+H)+., 96929-05-4

The synthetic route of 96929-05-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Antabio SAS; The designation of the inventor has not yet been filed; (149 pag.)EP3628672; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica