Synthesis and fungicidal activity of N,S-substituted α-thio-β-aminocrotonanilides was written by Pierce, James B.;Fanning, Robert J.;Davis, Robert Allan. And the article was included in Canadian Journal of Chemistry in 1975.Application In Synthesis of N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:
A number of N,S-substituted α-thio-β-aminocrotonanilides have been synthesized. Their fungicidal activity on a number of organisms has been studied and in general it has been found that it is inferior to that of the 1,4-oxathiins to which these compounds bear some structural similarities. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Application In Synthesis of N-Phenylbenzo[d]thiazol-2-amine).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Application In Synthesis of N-Phenylbenzo[d]thiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica